Have a Deeper Look at The History of Dapoxetine

Priligy (dapoxetine hydrochloride) is the first oral medication to be approved for the treatment of premature ejaculation. It was by chance that they discovered its ability to treat premature ejaculation, actually developed to treat depression. In this electronic resource (e-source), we’ll use the Viagra™ story to show how a medicine is designed, developed and produced As an active ingredient in Priligy, dapoxetine hydrochloride belongs to the class of medicines called selective serotonin reuptake inhibitors (SSRIs) with a short half-life of 1 or 2 hours, it is considered safe and sound for the treatment of premature ejaculation. At the initial development of dapoxetine, it has been credited by some sources to Eli Lilly chemist David Wong, who was also one of the developers of fluoxetine (Prozac). Like Prozac and other antidepressants such as Zoloft, Escitalopram and Paxil, dapoxetine is SSRI. In fact, considering the drug’s early development over a decade ago, Eli Lilly began phase I clinical trials for dapoxetine as an antidepressant medication. But dapoxetine was put on hold for a while and didn’t pan out as an antidepressant. But the same thing that leads to its failure as a psychopharmaceutical turned out to be the cause for its success as a premature ejaculation treatment.

Dapoxetine as a SRRI

Similar to other SSRIs, dapoxetine has the effect of delaying ejaculation and orgasm, and for a while doctors have been prescribing other SSRIs to treat premature ejaculation. But, as these antidepressants for treating this condition are not approved by the FDA, this is considered for “off label” use. As unlike other SSRIs, dapoxetine is easily and rapidly absorbed and eliminated by the body i.e. within few hours, rather than days. It was Karl Thor an Eli Lilly researcher who realized the drug’s potential as a treatment particularly for premature ejaculation. Due to its short residence in the body, it is considered unfeasible as an antidepressant. But on the other hand makes it more suitable for treating premature ejaculation. Eli Lilly resumed several trials with the remedy, but this time as a treatment for premature ejaculation.

Who Owns Priligy dapoxetine?

The patents and rights for the remedy have changed sometimes, and a number of pharmaceutical companies have owned the rights to dapoxetine. The drug was originated by Eli Lilly, but in 1998, to develop the drug as a premature ejaculation treatment, PPD GenuPro acquired the rights from Eli Lilly. But in 2001, PPD sold exclusive worldwide marketing and development rights for dapoxetine to an affiliate of Johnson & Johnson, ALZA Corporation. In 2003, PPD bought the patents for dapoxetine from Eli Lilly. PPD will still get milestone payments and drug royalties from ALZA, even if ALZA is the current license holder. However, if PPD exceed a certain amount Eli Lilly may possibly receive royalties from it. Now-a-days dapoxetine will be marketed in Canada by Janssen-Ortho Inc., in US by Ortho McNeil, and is currently being marketed in Europe by Janssen-Cilag; all are units of Johnson & Johnson.

Why Priligy (dapoxetine) is a safe drug?

Eli Lilly carried out the initial clinical trials of dapoxetine (phase I) for FDA approval. In collaboration with PPD GenuPro the phase II trials is executed. PPD presented the findings of two major trials in 2005 after continuing with phase III trials. Doses of 60mg or 100mg of dapoxetine were given to the men having age between 18 and 65 resulting in improved length of time to ejaculate. In 2008, dapoxetine had been tested with over 6,000 subjects in five major phase III trials. It was found that dapoxetine was not only increasing the intravaginal ejaculatory latency time but also improves overall sexual satisfaction and the sense of control over ejaculation.
It has been submitted for approval in the European Union and is being reviewed. In 2009, it’s been approved in Sweden, Finland, Austria, Portugal, Germany, Italy and Spain. And approvals are also anticipated in other European countries as well. In addition to this, in Canada, Australia, Mexico, Turkey and six other countries the submissions for approval have been done.

9 Sensational Yet Unknown Facts About Sex And Men

Men like the presence of a naked woman for sexual stimulation and they treat sex as one of their greatest accomplishments. Here’s exploring 9 sensational yet unknown facts about men and sex.

Young guys can suffer from impotency too

We tend to think impotency or erectile dysfunctions in men are associated with age, but this is wrong as young men can suffer too from this embarrassing sex problem. This is due to undue modern day stress, sedentary lifestyle, wrong diet, performance anxiety etc. As a result they are seeking for sex therapies and performance enhancing supplements. Besides impotency, young men are also suffering from ejaculation issues.

Sex in men depends on mood

When men are burdened with responsibilities they refrain from having sexual intercourse. When they are too stressed out then also they avoid having sex. So sex in men depends on their mood and how free their mind is.

It is common for men to do fake orgasms

The primary reason for faking it is not that good in bed as his partner expects him to be. Maybe he’s had excessive alcohol, he’s feeling nervous to reach the climax, or the side-effects of medicine he has taken to fight diabetes or high cholesterol.

Guys give more priority to the pleasure of their partner rather than their own

Men love pleasing their spouse or ladylove more during sex. They do not care about their satisfaction and that makes them magnanimous in bed.

Men are sensitive about their performance in bed

Since sex represents virility and masculinity for men, they try their best to perform in bed. They believe sex is a powerful weapon to keep a relationship positive and durable and if they fail in it people will start raising questions and doubts over their manliness.

Men’s self-respect is highly wrapped up in their capacity to do sex

When guys are declined by women sexually, they feel their manliness have been ripped apart.

Even those who are in serious commitment or relationships feel that their ladylove does not desire them sexually, it hurts their pride and ego to a great extent.

Men are evergreen when it comes to sex

Men in their 80s are two times more sexually active as that of women of the same age. This depicts that age does not induce their strength, stamina, desire, energy and effervescence to fade away.

Some men suffer from rare sexual problems

While impotency, premature ejaculation and loss of libido is common, some guys encounter with a rare sexual problem called retrograde ejaculation, where during sex their semen discharges back into the bladder, instead of being squeezed out. It is common in those guys who had a prostate surgery, or if they are suffering from blood sugar or multiple sclerosis.

Another rare sexual issue in guys is sexual anhedonia, a condition in which all their muscles contract during orgasm and ejaculation, and as a result they cannot feel the joy in bed. Antidepressants like Prozac trigger it.

Guys have lower libido as compared to women

In contrast to their female counterparts, guys have lesser libido or sexual urge. On the other hand, women are becoming progressive and sexually liberated and as a result they do not mind in making the first approach to their partner in bed.

There are many instances of relationships or commitments where females have the more urge, drive and desire than their men. However, this doesn’t mean they lack libido, it’s just that some women have a stronger libido.

Get Best Quality Vitamin D 3 Supplements Online

When you speak of sound health, you mean that you enjoy good physique, sound body system and strong bones. Vitamin d plays a major role here, so that you can maintain your health. Even after you consume vitamin d with your daily diet, there is a gnawing difference between what is needed by the body and what you eat. So, you need to get in touch with vitamin D3 supplements, which keep your bones strong and healthy. These supplements are needed to make sure that there is no shortage of the required amount in your body.

Where Can You Find Vitamin D? – A Common Question in Every Individuals Mind

Vitamin d comes from some natural sources as well as the food that you consume. However, due to the shortage of vitamins in the traditional food that you eat, you need to avail the supplements. The foods that provide you with this essential mineral include:

Liver: Liver of fish and animals contains a lot of vitamin D. However, the non-vegetarians are the only ones who enjoy them, while people who do not consume fish or meat are deprived of the nutrients. So, the vitamin D supplements bring the necessary amount of nutrients to them to ensure that there is no dearth of vitamins.
Cod liver oil: This is also a major source of vitamin D, but there are people who do not consume them and need the vitamin D3 supplements.
Fish oils: The same thing is valid for fish oils as in cod liver oils. The vegetarians need a stable supply of vitamin D to keep their bones strong. So, the best option is to get the vitamin D3 sources through the supplements.
Sunlight: This is also a major source of Vitamin D, and when you feel its shortage in your body, you must consume the external supplements.

Why Do You Need Vitamin D Supplements?

We are sure that this question will surely come to your mind at least once as why to use and what are the reasons behind the use of Vitamin D

Vitamin D is needed to regulate the functioning of calcium and phosphorous in the body. The functioning of all these elements are related and closely associated to each other. So, in order to maintain the quality of your bones, you need to avail the vitamin D3 sources.
Vitamin D is also needed to prevent a disease called rickets, which causes the bones to get deformed. It is common mostly in children. If the supplements are consumed in proper time and proportion, the chances of rickets are removed.
This is also needed to ensure that the bones of your body do not get eroded with age. As a person grows old, the bones tend to grow weaker. The Vitamin D supplements ensure that there is no such problem if you consume them after consulting with the doctors. So, you need to check out the online stores and get them.